Growth Culture Conditions and Nutrient Signaling Modulating Yeast Chronological Longevity
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چکیده
منابع مشابه
Growth Culture Conditions and Nutrient Signaling Modulating Yeast Chronological Longevity
The manipulation of nutrient-signaling pathways in yeast has uncovered the impact of environmental growth conditions in longevity. Studies using calorie restriction show that reducing glucose concentration of the culture media is sufficient to increase replicative and chronological lifespan (CLS). Other components of the culture media and factors such as the products of fermentation have also b...
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A decade ago, Mikhail Blagosklonny predicted that cellular senescence is driven by mitogenic pathways, when the cell cycle is blocked and actual growth is impossible [1]. In particular, the mitogenand nutrientsensing mTOR (Target of Rapamycin) pathway drives either cell mass growth or aging [2]. Rapamycin prevents conversion of reversible cell cycle arrest to senescence [3-11]. When the cell cy...
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Inhibition of growth signaling pathways protects against aging and age-related diseases in parallel with reduced oxidative stress. The relationships between growth signaling, oxidative stress and aging remain unclear. Here we report that in Saccharomyces cerevisiae, alterations in growth signaling pathways impact levels of superoxide anions that promote chronological aging and inhibit growth ar...
متن کاملCulture Conditions and Growth Rates
Because of the reactivity of oxygen with biologically impor tan t compounds, e.g. unsaturated lipids, SH-conta in ing proteins and cofactors, and redox compounds (see review by Haugaard , 1968), cells in aerobic envi ronments require some mean(s) for protect ion from indiscr iminate oxidation. Since the superoxide free radical, O2, is apparently a major product of the reaction of 02 with reduce...
متن کاملCulture Conditions and Growth Rates
Because of the reactivity of oxygen with biologically impor tan t compounds, e.g. unsaturated lipids, SH-conta in ing proteins and cofactors, and redox compounds (see review by Haugaard , 1968), cells in aerobic envi ronments require some mean(s) for protect ion from indiscr iminate oxidation. Since the superoxide free radical, O2, is apparently a major product of the reaction of 02 with reduce...
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ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2012
ISSN: 1942-0900,1942-0994
DOI: 10.1155/2012/680304